The female transcript, unlike the male, contains an exon (exon 5) whose sequence is highly conserved in all Anopheles mosquitoes so far analyzed. In the human malaria vector Anopheles gambiae, the gene doublesex ( Agdsx) encodes two alternatively spliced transcripts, dsx-female ( AgdsxF) and dsx-male ( AgdsxM), that control differentiation of the two sexes.
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